Spence Breast Development Clinic Itsukaichi Mei... ((exclusive)) «SAFE ✮»

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| Timeline | Clinical Milestones | |---|---| | | Minor breast budding (progression to Tanner Stage 3); slight rise in estradiol; improved self‑esteem scores (BIDS ↓ 4 points). | | 3–6 months | Palpable breast tissue growth, possible onset of areolar contouring; first menstrual bleed (if progesterone added after 6 months). | | 6–12 months | Tanner Stage 4 (if therapy effective); stable menstrual cycles (every 28–35 days); bone density maintenance or modest increase (DEXA Z‑score ≥ ‑1.0). | | 12–24 months | Tanner Stage 5 (full adult breast development); resolution of body‑image distress (BIDS < 5); decision on any corrective surgery if asymmetry remains problematic. | Spence Breast Development Clinic Itsukaichi Mei...