Antivirus software sometimes flags the .exe as a false positive and deletes it. Check your protection history or "Quarantine" folder to see if PlayGTAV.exe was blocked. If so, restore it and add the game folder to your exclusions list .

GTA V follows the lives of three protagonists: Michael De Santa, Franklin Clinton, and Trevor Phillips. The game's narrative is set in the fictional city of Los Santos, where the three characters become embroiled in a series of heists and crimes. As players progress through the game, they can switch between the three characters, each with their unique skills and abilities.