If you’re using a (e.g., from GOG offline installer or a scene release), the features are identical — but there are differences:

Avoid shady “portable repacks” from torrent sites. Many are bundled with malware or missing critical files. Always verify checksums of Fallout4.exe (should be around 45-50MB for 1.10.163).

Run MO2 once as administrator, then go to Settings > Paths and manually browse to the portable folder. Then create a mods subfolder inside it.

[RU/ENG] Откат до 1.10.163 (Downgrade) - Steam Community

It looks like you’re asking about the included in Fallout 4 patch version 1.10.163 — specifically in relation to a portable version (a repack or modified executable not requiring the Steam launcher).