Do not run the emulator while gaming. Close x360ce.exe. Launch the game normally. If you hear a "Device connected" sound (or rumble), the emulation is working.
💡 : Keep the x360ce application closed while playing; the generated .dll file does the work in the background once configured. If you'd like, let me know: Which game you are trying to play? Is your controller generic, PlayStation, or something else ? Are you getting a specific error message ? [PSA] x360ce works well - bind analog axis : r/thedivision x360ce 3.2.9.81