David Bioinformatics Resources [new] Here
A researcher studying breast cancer metastasis identifies 300 genes upregulated in invasive cells. Using DAVID, they find that the top annotation cluster is "extracellular matrix reorganization" (collagens, MMPs, integrins). A secondary cluster reveals "epithelial-to-mesenchymal transition" (Snail, Twist, Vimentin). These results immediately guide the researcher toward validated hypotheses for drug targeting.
(Database for Annotation, Visualization, and Integrated Discovery) is an essential web-based bioinformatics platform designed to provide functional interpretation for large lists of genes. Since its debut in 2003, it has become one of the most widely used tools in genomics, cited in over 72,000 papers as of 2024. The Core: DAVID Knowledgebase david bioinformatics resources
